|
T22733 |
DL-AP5
|
|
NMDAR
|
|
DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects. |
|
T11516 |
GV-196771A
|
|
NMDAR
|
|
|
|
TP1905 |
BW-180C
|
DADLE |
Opioid Receptor
|
|
BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo. |
|
T21380 |
Pravadoline
|
WIN 48098-6,WIN48098-6,WIN-48098-6 |
Cannabinoid Receptor
|
|
Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan... |
|
T23076L |
Nociceptin (1-7) acetate
|
|
Opioid Receptor
|
|
Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity. |
|
T39284 |
EST73502 HCl
|
|
Opioid Receptor
|
|
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity. |
|
T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
|
TP1212 |
N-Boc-Phe-Leu-Phe-Leu-Phe
|
Boc-FLFLF |
Others
|
|
N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin. Boc-Phe-Leu-Phe-Leu-Phe is used extensive... |
|
T10572 |
BMT-124110
|
|
AAK1 (AP2 associated kinase 1)
|
|
BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an... |
|
T34081 |
Piromelatine
|
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
|
T4436 |
RO1138452
|
CAY10441 |
Others
,
Prostaglandin Receptor
|
|
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli... |
|
T27363 |
FR 64822
|
FR-64822,FR64822 |
|
|
FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptiv... |
|
T72151 |
(D-Met2,Pro5)-Enkephalinamide
|
|
|
|
(D-Met2,Pro5)-Enkephalinamide, a highly potent opiate agonist, exhibits significant antinociceptive activity. |
|
T27968 |
M-5011
|
T-3788,S-MTPPA,M 5011,M-5011C |
|
|
M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially i... |
|
T68206 |
Arbortristoside A
|
|
|
|
Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and ... |
|
T72007 |
COR167
|
|
|
|
COR167 is a CB2 agonist. It displayed potent immunomodulatory activity on immune cells from healthy subjects and patients with multiple sclerosis. It also showed protective effects on rat brain tissues toward ischemia an... |
|
T15165 |
DPI-3290
|
Org 41793 |
Opioid Receptor
|
|
DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally... |
|
T14691 |
BMT-090605
|
|
Others
|
|
BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-09... |
|
T37392 |
Purotoxin 1
|
|
|
|
Purotoxin 1, isolated from wolf spider venom, is a P2X3 receptor inhibitor that exhibits antinociceptive activity in animal models of inflammatory pain. |
|
T37092 |
20-HEPE
|
|
|
|
20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in CO... |
|
T63231 |
LPA5 antagonist 1
|
|
|
|
LPA5 antagonist 1 is a selective and potent lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 32 nM. LPA5 antagonist 1 has high brain permeability and antinociceptive activity and can be used to st... |
|
T9669 |
EST73502 hydrochloride
|
|
|
|
EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respecti... |
|
TP1901 |
Hemopressin(rat)
|
Hemopressin (rat) |
|
|
Hemopressin(rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. |
|
TP1900 |
Hemopressin (human, mouse)
|
|
|
|
Hemopressin(human, mouse) is a bioactive endogenous peptide substrate for endopeptidase, neurolysin and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. |
|
T38210 |
Hodgkinsine B
|
|
|
|
Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg.
1.Kodanko, J.J., Hie... |
